Association between large vessel vasculitis and inflammatory bowel disease: a case-control study

Maillet, F; Nguyen, Y; Espitia, O; Perard, L; Salvarani, C; Rivière, E; Ndiaye, D; Durel, CA; Guilpain, P; Mouthon, L; Kernder, A; Loricera, J; Cohen, P; Melki, I; de Moreuil, C; Limal, N; Mékinian, A; Costedoat-Chalumeau, N; Morel, N; Boutemy, J; Raffray, L; Allain, JS; Devauchelle, V; Kone-Paut, I; Fabre, M; Durel, M; Dossier, A; Abad, S; Visentini, M; Bigot, A; Yildiz, H; Fain, O; Samson, M; Gondran, G; Abitbol, V; Terrier, B

doi:10.1093/rheumatology/keaf030

Vasculitis & polymyalgia rheumatica

Association between large vessel vasculitis and inflammatory bowel disease: a case-control study

Rheumatology (Oxford)Published 3 Feb 2025Retrospective case-control study

An erratum to this article was published (Rheumatology (Oxford), 8 Jan 2026 ↗)

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Authors' conclusion

This study identifies specific clinical and imaging characteristics of LVV-IBD patients, in particular a more severe vascular presentation of GCA-IBD patients compared with iGCA patients.

Study context

Population: Patients with large vessel vasculitis (LVV) (Takayasu arteritis or GCA) and IBD from European countries; controls with isolated LVV
Participants: 39 / 93 / 12 / 52

Comparison: LVV with IBD vs isolated LVV
TA-IBDn = 39
Isolated TA (iTA)n = 93reference
GCA-IBDn = 12
Isolated GCA (iGCA)n = 52reference
Outcome: Clinical and imaging characteristics of LVV-IBD vs isolated LVV: age at TA diagnosis and upper limb claudication (TA-IBD vs iTA); arterial thickening or stenosis (GCA-IBD vs iGCA)

Methodological detailsobservational, multicentre

Observational
Multicentre

Main finding

As reported in the abstract

Median age at TA diagnosis

27 vs 37 years

P < 0.001

TA-IBD vs iTA

Upper limb claudication

36% vs 12%

P = 0.006

TA-IBD vs iTA

Arterial thickening or stenosis

75% vs 30%

P = 0.044

GCA-IBD vs iGCA

Observational data: associations, not effects.

Further findings

Outcome	← Lower risk ←→ Higher risk →	aHR (CI)
LVV relapse (multivariate analysis)GCA-IBDvs iGCA	0.10.31310	0.62 (0.13–2.83)
LVV relapse (multivariate analysis)TA-IBDvs iTA	0.10.31310	0.92 (0.44–1.89)
	0.10.31310Adjusted hazard ratio (log scale)

Outcome	TA-IBD	GCA-IBD
LVV occurring after IBD	56%	75%
Interval from IBD to LVV	median 1 (IQR 1–7) year	median 8.6 (IQR 1–17.7) years
IBD type
Crohn's disease	67%	— not stated in the abstract
Ulcerative colitis	— not stated in the abstract	58%

— not stated in the abstract

LVV relapse (multivariate analysis)

IBD not associated with a higher LVV relapse rate

LVV occurring despite IBD treatment

GC: 36%
AZA: 25%
TNFi: 29%

Original publication

Association between large vessel vasculitis and inflammatory bowel disease: a case-control study. Rheumatology (Oxford). Published 3 February 2025. doi:10.1093/rheumatology/keaf030

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