Spondyloarthritis & psoriatic arthritis
An ankylosing spondylitis risk variant alters osteoclast differentiation
Main finding · AS onset risk by PSMB1 rs12717 genotypeResult — go to the resultOdds ratio 1.89Authors' conclusion
These results reveal a novel understanding of the bone formation and reabsorbing imbalance in AS.
Study context
- Population
- AS patients and controls without rheumatic and arthritis disease
- Participants
- 1,037 vs 1,014
- Comparison
- AS patients vs controls without rheumatic and arthritis disease
- ASn = 1,037
- Controlsn = 1,014reference
- Outcome
- Association of variants in non-MHC proteasome genes with AS
Methodological detailsgenetic association, functional assays (dual-luciferase reporter, immunoblot, osteoclastogenesis)
- Genetic association
- Functional assays (dual-luciferase reporter, immunoblot, osteoclastogenesis)
Main finding
AS onset risk by PSMB1 rs12717 genotype
Odds ratio
1.89
P = 0.0047
As reported in the abstract
Observational data: associations, not effects.
Further findings
HLA-B27 positivity among AS patients
- HLA-B27-positive subjects, % of patients
- 90.0%
Age of AS onset
- Main age of AS onset between 16 and 35 years
Original publication
An ankylosing spondylitis risk variant alters osteoclast differentiation. Rheumatology (Oxford). Published 19 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →