A comparison of meta-analyses on articular treatments for knee osteoarthritis-related pain
Authors' conclusion
Substantial discrepancies exist between overlapping MAs evaluating local treatments for KOA-related pain.
Study context
- Population
- Meta-analyses (MAs) evaluating local treatments for knee OA-related pain, MEDLINE from inception to March 2025566 pairwise comparisons
- Participants
- 81 participants
- Outcome
- Concordance of pain outcome results between overlapping MAs (pairwise comparisons)
Methodological detailscomparison of meta-analyses, pairwise comparisons of overlapping MAs
- Comparison of meta-analyses
- Pairwise comparisons of overlapping MAs
Pooled result
As reported in the abstract
- MAs included; pairwise comparisons across 15 treatment themes
- 81 MAs; 566 pairwise comparisons
- Pain outcome comparisons with identical results (of 113 possible)
- 32 (28.3%)
- Pain outcome comparisons completely different (of 113 possible)
- 36 (31.9%)
- Search strategy unavailable
- 18.2% of pairwise comparisons
- Search strategy identical
- 2 (0.4%)
- Database searches identical
- 6.9% of comparisons
Original publication
A comparison of meta-analyses on articular treatments for knee osteoarthritis-related pain. Joint Bone Spine. Published 31 August 2026. doi:10.
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